This treaty created a nuclear-weapon-free zone in Latin America and the Caribbean. The Treaty of Tlatelolco was the first international agreement that aimed at excluding nuclear weapons from an inhabited region of the globe. The member states accept the application of International Atomic Energy Agency safeguards for all their nuclear activities to assist in verifying compliance with the treaty. The treaty also establishes a regional organization, the Agency for the Prohibition of Nuclear Weapons in Latin America (OPANAL), to help ensure compliance with its provisions.