When the differences between the treatment and control groups other than the treatment produce differences in response that are not distinguishable from the effect of the treatment, those differences between the groups are said to be confounded with the effect of the treatment (if any). For example, prominent statisticians questioned whether differences between individuals that led some to smoke and others not to (rather than the act of smoking itself) were responsible for the observed difference in the frequencies with which smokers and non-smokers contract various illnesses. If that were the case, those factors would be confounded with the effect of smoking. Confounding is quite likely to affect observational studies and experiments that are not randomized. Confounding tends to be decreased by randomization. See also Simpson's Paradox.